prohibitin is a mitochondrial protein.in rats who were treated ischemia tolerance ıt was seen there was prohibitin upregulating.prohibitin reduces relesing of radical oxygen spices from mitichondria.ıt is thought that prohibitin is an endogeneus protective protein that support mitochondria's function.besides the effects of prohibitin in nerve tissue is not known exactl it is argued it protect neurons.Prohibitin reduces mitochondrial free radical production and protects brain cells from different injury modalities Ping Zhou,1,2 Liping Qian,1,2 Marilena D’Aurelio,2 Sunghee Cho,1,2,* Gang Wang,1,2 Giovanni Manfredi,2 Virginia Pickel,1,2 and Costantino Iadecola1,2